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  • Relationship between progression of brain white matter changes and late life-depression: 3-year results from the LADIS study

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    TeodorczukPUB970.pdf (93.18Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Firbank, Michael J
    Teodorczuk, Andrew
    van der Flier, Wiesje M
    Gouw, Alida A
    Wallin, Anders
    Erkinjuntti, Timo
    Inzitari, Domenico
    Wahlund, Lars-Olof
    Pantoni, Leonardo
    Poggesi, Anna
    Pracucci, Giovanni
    Langhorne, Peter
    O'Brien, John T
    Griffith University Author(s)
    Teodorczuk, Andrew
    Year published
    2012
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    Abstract
    Background: Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear. Aims: To investigate the relationship between baseline and incident depression and progression of white matter changes. Method: In a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression ...
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    Background: Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear. Aims: To investigate the relationship between baseline and incident depression and progression of white matter changes. Method: In a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression of WMC was measured using the modified Rotterdam Progression scale. Results: Progression of WMC was significantly associated with incident depression during year 3 of the study (P = 0.002) and remained significant after controlling for transition to disability, baseline WMC and baseline history of depression. There was no significant association between progression of WMC and GDS score, and no significant relationship between progression of WMC and history of depression at baseline. Conclusions: Our results support the vascular depression hypothesis and implicate WMC as causal in the pathogenesis of late-life depression.
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    Journal Title
    British Journal of Psychiatry
    Volume
    201
    Issue
    1
    DOI
    https://doi.org/10.1192/bjp.bp.111.098897
    Copyright Statement
    © 2012 The Royal College of Psychiatrists. This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org
    Subject
    Biomedical and clinical sciences
    Clinical sciences not elsewhere classified
    Psychology
    Publication URI
    http://hdl.handle.net/10072/173834
    Collection
    • Journal articles

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