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  • Investigation of the potential of a novel 48 kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae

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    Author(s)
    Webb, Dianne C
    Otczyk, Diana C
    Cripps, Allan W
    Griffith University Author(s)
    Cripps, Allan W.
    Otczyk, Diana
    Year published
    2007
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    Abstract
    This study determined the conservation and protective efficacy of a 48 kDa nontypable Haemophilus influenzae (NTHi) protein (P48). This protein was highly conserved across the strains of NTHi examined and mucosal immunization with recombinant P48 (rP48) significantly reduced the numbers of viable NTHi recovered from the lung following challenge. rP48 induced predominantly an IgG2a antibody response that correlated with the reduction in the number of viable NTHi in the lung. These antibodies were not bactericidal against NTHi. The results suggest that P48 warrants further investigation as a vaccine component for NTHi disease.This study determined the conservation and protective efficacy of a 48 kDa nontypable Haemophilus influenzae (NTHi) protein (P48). This protein was highly conserved across the strains of NTHi examined and mucosal immunization with recombinant P48 (rP48) significantly reduced the numbers of viable NTHi recovered from the lung following challenge. rP48 induced predominantly an IgG2a antibody response that correlated with the reduction in the number of viable NTHi in the lung. These antibodies were not bactericidal against NTHi. The results suggest that P48 warrants further investigation as a vaccine component for NTHi disease.
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    Journal Title
    Vaccine
    Volume
    25
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#description
    DOI
    https://doi.org/10.1016/j.vaccine.2007.02.048
    Copyright Statement
    © 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences
    Agricultural and Veterinary Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/17384
    Collection
    • Journal articles

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