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dc.contributor.authorAshton, Kevinen_US
dc.contributor.authorPeart, Jasonen_US
dc.contributor.authorRay Morrison, R.en_US
dc.contributor.authorPaul Matherne, G.en_US
dc.contributor.authorR. Blackburn, Michaelen_US
dc.contributor.authorHeadrick, Johnen_US
dc.date.accessioned2017-04-24T10:09:10Z
dc.date.available2017-04-24T10:09:10Z
dc.date.issued2007en_US
dc.identifier.issn00222828en_US
dc.identifier.doi10.1016/j.yjmcc.2006.12.012en_US
dc.identifier.urihttp://hdl.handle.net/10072/17421
dc.description.abstractThe adenosine receptor system has been attributed with a broad range of both physiological and so-called 'retaliatory' functions in the heart and vessels. Despite many years of research, the precise roles of adenosine within the cardiovascular system continue to be debated, and new functions are continually emerging. Adenosine acts via 4 known G-protein-coupled receptor (GPCR) sub-types: A1, A2A, A2B, and A3 adenosine receptors (ARs). In addition to roles in cardiovascular control, these receptors may represent therapeutic targets, having been attributed with roles in modifying cell death and injury, inflammatory processes, and cardiac and vascular remodeling during/after ischemic or hypoxic insult. A number of models have been developed in which AR sub-types and adenosine handling enzymes have been genetically deleted or transgenically overexpressed in an attempt to more equivocally identify the regulatory functions of these proteins, to identify their potential value as therapeutic targets, and to uncover new regulatory functions of this receptor family. Findings generally support current dogma regarding cardioprotection via A1 and A3ARs, and coronary vasoregulation via A2AR sub-types. However, some outcomes are both novel and controversial. This review outlines AR-modified murine models currently under study from the perspective of cardiovascular phenotype.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom693en_US
dc.relation.ispartofpageto705en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalJournal of Molecular and Cellular Cardiologyen_US
dc.relation.ispartofvolume42en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode320503en_US
dc.subject.fieldofresearchcode320603en_US
dc.titleGenetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issuesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2015-05-05T05:05:14Z
gro.hasfulltextNo Full Text


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