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  • Optimisation of oral immunization through receptor-mediated targeting of M cells

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    Author(s)
    Foxwell, A Ruth
    Cripps, Allan W
    Kyd, Jennelle M
    Griffith University Author(s)
    Cripps, Allan W.
    Kyd, Jennelle M.
    Year published
    2007
    Metadata
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    Abstract
    Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate ...
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    Only a small number of oral vaccines are available for routine immunisations despite a significant research effort and a number of obvious advantages over parenteral vaccination. The major roadblock in the development of oral vaccines has been mostly attributed to a lack of ability to specifically target antigen to the mucosal immune system of the gastrointestinal tract. This commentary examines the accessing of M cells through receptor interaction on the apical surface of the cell in order to enhance the efficiency and efficacy of oral immunisation. Three challenges have been identified (i) the availability of appropriate experimental models to study M cell targeting and transcytosis; (ii) appropriate tools for investigating the specificity of targeting; and (iii) the identification of priority targets on the apical surface of M cells.
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    Journal Title
    Human Vaccines
    Volume
    3
    Issue
    5
    Publisher URI
    http://www.landesbioscience.com/journals/vaccines
    DOI
    https://doi.org/10.4161/hv.3.5.4358
    Copyright Statement
    © The Author(s) 2007 . The attached file is posted here with permission of the copyright owners for your personal use only. No further distribution permitted. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Immunology
    Medical Microbiology
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/17422
    Collection
    • Journal articles

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