[Ag(I)(Et2PCH2CH2PPh2)2]NO3: An Antimitochondrial Silver(I) Complex

Abstract

The silver(I) complex [Ag(eppe)2]NO3 (eppe = Et2PCH2CH2PPh2) is shown by X-ray crystallography to be tetrahedral with Ag - PEt2 and Ag - P Ph2 bond lengths of 2.482 and 2.518 Å, respectively. The complex is selectively antimitochondrial and inhibits the growth of a number of yeast strains in non-fermentable media at concentrations as low as 2.5 μΜ and induces the mitochondrial mutation petite The effect is largely reversed by the presence of aspirin. The complex is shown to be stable in the cell culture media and in the presence of glutathione, but readily reacts with disulfides of oxidized glutathione and serum albumin. Surprisingly, neither [Au(eppe)2]Cl nor [Au(eppe)2]Cl (dppe = Ph2PCH2CH2PPh2) showed any mitochondrial selectivity in the same screening protocol.