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dc.contributor.authorBerners-Price, Sue
dc.contributor.authorCollier, D.
dc.contributor.authorMazid, M.
dc.contributor.authorSadler, P.
dc.contributor.authorSue, R.
dc.contributor.authorWilkie, D.
dc.date.accessioned2017-09-25T03:01:31Z
dc.date.available2017-09-25T03:01:31Z
dc.date.issued1994
dc.identifier.urihttp://hdl.handle.net/10072/176096
dc.description.abstractThe silver(I) complex [Ag(eppe)2]NO3 (eppe = Et2PCH2CH2PPh2) is shown by X-ray crystallography to be tetrahedral with Ag - PEt2 and Ag - P Ph2 bond lengths of 2.482 and 2.518 Å, respectively. The complex is selectively antimitochondrial and inhibits the growth of a number of yeast strains in non-fermentable media at concentrations as low as 2.5 μΜ and induces the mitochondrial mutation petite The effect is largely reversed by the presence of aspirin. The complex is shown to be stable in the cell culture media and in the presence of glutathione, but readily reacts with disulfides of oxidized glutathione and serum albumin. Surprisingly, neither [Au(eppe)2]Cl nor [Au(eppe)2]Cl (dppe = Ph2PCH2CH2PPh2) showed any mitochondrial selectivity in the same screening protocol.en_US
dc.languageEnglishen_US
dc.relation.ispartofconferencenameNot Knownen_US
dc.subject.fieldofresearchCHEMICAL SCIENCESen_US
dc.subject.fieldofresearchcode030000en_US
dc.title[Ag(I)(Et2PCH2CH2PPh2)2]NO3: An Antimitochondrial Silver(I) Complexen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conference Publications (Extract Paper)en_US
dc.type.codeE - Conference Publicationsen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.hasfulltextNo Full Text
gro.griffith.authorBerners-Price, Sue J.


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