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dc.contributor.authorThomas, Rebecca M
dc.contributor.authorTitball, Richard W
dc.contributor.authorOyston, Petra CF
dc.contributor.authorGriffin, Kate
dc.contributor.authorWaters, Emma
dc.contributor.authorHitchen, Paul G
dc.contributor.authorMichell, Stephen L
dc.contributor.authorGrice, I Darren
dc.contributor.authorWilson, Jennifer C
dc.contributor.authorPrior, Joann L
dc.date.accessioned2017-09-06T00:51:29Z
dc.date.available2017-09-06T00:51:29Z
dc.date.issued2007
dc.date.modified2012-02-10T01:43:33Z
dc.identifier.issn0019-9567
dc.identifier.doi10.1128/IAI.01241-06
dc.identifier.urihttp://hdl.handle.net/10072/17700
dc.description.abstractWe have determined the sequence of the gene cluster encoding the O antigen in Francisella novicida and compared it to the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis. Immunization with purified lipopolysaccharide (LPS) from F. tularensis subsp. tularensis or F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida, respectively. The LPS from F. tularensis subsp. tularensis did not confer protection against challenge with F. novicida, and the LPS from F. novicida did not confer protection against challenge with F. tularensis subsp. holarctica. Allelic replacement mutants of F. tularensis subsp. tularensis or F. novicida which failed to produce O antigen were attenuated, but exposure to these mutants did not induce a protective immune response. The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dc.publisher.placeWashington, USA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom371
dc.relation.ispartofpageto378
dc.relation.ispartofissue1
dc.relation.ispartofjournalInfection and immunity
dc.relation.ispartofvolume75
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode07
dc.titleThe immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPublished
gro.rights.copyright© 2007 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2007
gro.hasfulltextFull Text
gro.griffith.authorGrice, Darren D.
gro.griffith.authorWilson, Jenny C.


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