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dc.contributor.authorThomas, Rebecca
dc.contributor.authorTitball, Richard
dc.contributor.authorC. F. Oyston, Petra
dc.contributor.authorGriffin, Kate
dc.contributor.authorWaters, Emma
dc.contributor.authorHitchen, Paul
dc.contributor.authorL. Michell, Stephen
dc.contributor.authorGrice, Darren
dc.contributor.authorWilson, Jenny
dc.contributor.authorL. Prior, Joann
dc.date.accessioned2017-09-06T00:51:29Z
dc.date.available2017-09-06T00:51:29Z
dc.date.issued2007
dc.date.modified2012-02-10T01:43:33Z
dc.identifier.issn00199567en_US
dc.identifier.doi10.1128/IAI.01241-06en_US
dc.identifier.urihttp://hdl.handle.net/10072/17700
dc.description.abstractWe have determined the sequence of the gene cluster encoding the O antigen in Francisella novicida and compared it to the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis. Immunization with purified lipopolysaccharide (LPS) from F. tularensis subsp. tularensis or F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida, respectively. The LPS from F. tularensis subsp. tularensis did not confer protection against challenge with F. novicida, and the LPS from F. novicida did not confer protection against challenge with F. tularensis subsp. holarctica. Allelic replacement mutants of F. tularensis subsp. tularensis or F. novicida which failed to produce O antigen were attenuated, but exposure to these mutants did not induce a protective immune response. The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeWashington, USAen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom371en_US
dc.relation.ispartofpageto378en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalInfection and immunityen_US
dc.relation.ispartofvolume75en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode270206en_US
dc.subject.fieldofresearchcode270304en_US
dc.subject.fieldofresearchcode250302en_US
dc.titleThe immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigensen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPublisheden_US
gro.rights.copyright© 2007 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2007
gro.hasfulltextFull Text


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