The Invitro Cytotoxicity and DNA Alkylating Ability of the Simplest Functional Analogues of the Seco CC-1065 Alkylating Subunit
Author(s)
White, Rodney
Parsons, Peter G.
Prakash, Arungundrum S.
Young, David
Year published
1995
Metadata
Show full item recordAbstract
The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more functionalised seco analogues of the antitumor agent CC-1065 alkylating subunit.
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume
5
Issue
16
Subject
Chemical Sciences
Medicinal and Biomolecular Chemistry
Organic Chemistry
Pharmacology and Pharmaceutical Sciences