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dc.contributor.authorNeuzil, Jirien_US
dc.contributor.authorWiden, Ceciliaen_US
dc.contributor.authorGellert, Ninaen_US
dc.contributor.authorCowie, Emmaen_US
dc.contributor.authorZobalova, Renataen_US
dc.contributor.authorDong, Lan-fengen_US
dc.contributor.authorWang, Xiufangen_US
dc.contributor.authorLidebjer, Carolineen_US
dc.contributor.authorDalen, Helgeen_US
dc.contributor.authorHeadrick, Johnen_US
dc.contributor.authorK. Witting, Paulen_US
dc.date.accessioned2017-04-24T08:09:09Z
dc.date.available2017-04-24T08:09:09Z
dc.date.issued2007en_US
dc.date.modified2009-09-09T07:17:28Z
dc.identifier.issn13510002en_US
dc.identifier.doi10.1179/135100007X200227en_AU
dc.identifier.urihttp://hdl.handle.net/10072/17784
dc.description.abstractIschemia-reperfusion (I/R) is a condition leading to serious complications due to death of cardiac myocytes. We used the cardiomyocyte-like cell line H9c2 to study the mechanism underlying cell damage. Exposure of the cells to simulated I/R lead to their apoptosis. Over-expression of Bcl-2 and Bcl-xL protected the cells from apoptosis while over-expression of Bax sensitized them to programmed cell death induction. Mitochondria-targeted coenzyme Q (mitoQ) and superoxide dismutase both inhibited accumulation of reactive oxygen species (ROS) and apoptosis induction. Notably, mtDNA-deficient cells responded to I/R by decreased ROS generation and apoptosis. Using both in situ and in vivo approaches, it was found that apoptosis occurred during reperfusion following ischemia, and recovery was enhanced when hearts from mice were supplemented with mitoQ. In conclusion, I/R results in apoptosis in cultured cardiac myocytes and heart tissue largely via generation of mitochondria-derived superoxide, with ensuing apoptosis during the reperfusion phase.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherW. S. Maney & Son Ltden_US
dc.publisher.placeLondon, United Kingdomen_US
dc.publisher.urihttp://www.maney.co.uk/search?fwaction=show&fwid=209en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom148en_US
dc.relation.ispartofpageto162en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalRedox Reporten_US
dc.relation.ispartofvolume12en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode320307en_US
dc.subject.fieldofresearchcode320602en_US
dc.titleMitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injuryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2007 Maney Publishing. The attached file is reproduced here in accordance with the copyright policy of the publisher.Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2007
gro.hasfulltextNo Full Text


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