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dc.contributor.authorFernandez, Francescaen_US
dc.contributor.authorCurtain, Roben_US
dc.contributor.authorColson, Natalieen_US
dc.contributor.authorOvcaric, Mickyen_US
dc.contributor.authorMacMillan, Johnen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.editorJigisha Patel, MRCP PhDen_US
dc.date.accessioned2017-04-24T11:20:34Z
dc.date.available2017-04-24T11:20:34Z
dc.date.issued2007en_US
dc.date.modified2008-07-09T02:45:46Z
dc.identifier.issn14712350en_US
dc.identifier.doi10.1186/1471-2350-8-57en_AU
dc.identifier.urihttp://hdl.handle.net/10072/17786
dc.description.abstractBackground Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci. The type 2 FHM (FHM-2) susceptibility locus maps to chromosome 1q23 and mutations in the ATP1A2 gene at this site have recently been implicated. We have previously provided evidence of linkage of typical migraine (predominantly MA) to microsatellite markers on chromosome 1, in the 1q31 and 1q23 regions. In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions using an association analysis approach. Methods We have genotyped a large population of case-controls (243 unrelated Caucasian migraineurs versus 243 controls) examining a set of 5 single nucleotide polymorphisms (SNPs) and the Fas Ligand dinucleotide repeat marker, located within the chromosome 1q23 and 1q31 regions. Results Several genes have been studied including membrane protein (ATP 1 subtype A4 and FasL), cytoplasmic glycoprotein (CASQ 1) genes and potassium (KCN J9 and KCN J10) and calcium (CACNA1E) channel genes in 243 migraineurs (including 85% MA and 15% of migraine without aura (MO)) and 243 matched controls. After correction for multiple testing, chi-square results showed non-significant P values (P > 0.008) across all SNPs (and a CA repeat) tested in these different genes, however results with the KCN J10 marker gave interesting results (P = 0.02) that may be worth exploring further in other populations. Conclusion These results do not show a significant role for the tested candidate gene variants and also do not support the hypothesis that a common chromosome 1 defective gene influences both FHM and the more common forms of migraine.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent288362 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Centralen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://www.biomedcentral.com/1471-2350/8/57/abstract/en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto8en_US
dc.relation.ispartofjournalBMC Medical Geneticsen_US
dc.relation.ispartofvolume8en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320799en_US
dc.subject.fieldofresearchcode270210en_US
dc.titleAssociation analysis of chromosome 1 migraine candidate genesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 57.en_AU
gro.rights.copyrightCopyright 2007 Fernandez et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
gro.date.issued2007
gro.hasfulltextFull Text


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