Co-culture of Cancer Cells with Normal Human Osteoblasts Results in Over-expression of Matrix Metalloproteinase-2
Abstract
Introduction: understanding mechanisms of cancer metastasis is fundamental to preventing cancer spread, particularly into jaw bones: knowledge from our previous prostate cancer studies may assist in understanding the progression of head and neck squamous cancers. MMP-2 or -9 have shown potential roles in the spread of a variety of cancers. Aim: to determine the expression of MMP-2 in cancer cells following interactions between cancer and normal bone cells in vitro at the protein and moledular levels. Conclusion: the over-expression of MMP-2 in prostate cancer cells following interaction with osteoblasts suggests this ...
View more >Introduction: understanding mechanisms of cancer metastasis is fundamental to preventing cancer spread, particularly into jaw bones: knowledge from our previous prostate cancer studies may assist in understanding the progression of head and neck squamous cancers. MMP-2 or -9 have shown potential roles in the spread of a variety of cancers. Aim: to determine the expression of MMP-2 in cancer cells following interactions between cancer and normal bone cells in vitro at the protein and moledular levels. Conclusion: the over-expression of MMP-2 in prostate cancer cells following interaction with osteoblasts suggests this enzyme played an important role in the cancer progression.
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View more >Introduction: understanding mechanisms of cancer metastasis is fundamental to preventing cancer spread, particularly into jaw bones: knowledge from our previous prostate cancer studies may assist in understanding the progression of head and neck squamous cancers. MMP-2 or -9 have shown potential roles in the spread of a variety of cancers. Aim: to determine the expression of MMP-2 in cancer cells following interactions between cancer and normal bone cells in vitro at the protein and moledular levels. Conclusion: the over-expression of MMP-2 in prostate cancer cells following interaction with osteoblasts suggests this enzyme played an important role in the cancer progression.
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Conference Title
Co-culture of Cancer Cells with Normal Human Osteoblasts Results in Over-expression of Matrix Metalloproteinase-2