Vanillic Acid Derivatives from the Green Algae Cladophora socialis As Potent Protein Tyrosine Phosphatase 1B Inhibitors

Author(s)
Feng, Yunjiang
Carroll, Anthony R
Addepalli, Rama
Fechner, Gregory A
Avery, Vicky M
Quinn, Ronald J
Griffith University Author(s)
Year published
2007
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Abstract
A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin cell signalling. Compounds 1 and 2 had IC50 values of 3.7 and 1.7 uM, respectively.
Journal Title
Journal of Natural Products
Volume
70
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Copyright Statement
© 2007 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page after publication. Use hypertext link above to access the ACS website.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
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