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Vanillic Acid Derivatives from the Green Algae Cladophora socialis As Potent Protein Tyrosine Phosphatase 1B Inhibitors

dc.contributor.authorFeng, Yunjiang
dc.contributor.authorCarroll, Anthony R
dc.contributor.authorAddepalli, Rama
dc.contributor.authorFechner, Gregory A
dc.contributor.authorAvery, Vicky M
dc.contributor.authorQuinn, Ronald J
dc.contributor.editorA Kinghorn Douglas
dc.date.accessioned2017-05-03T13:04:32Z
dc.date.available2017-05-03T13:04:32Z
dc.date.issued2007
dc.date.modified2009-08-26T07:04:04Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np070225o
dc.identifier.urihttp://hdl.handle.net/10072/17893
dc.description.abstractA novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae, Cladophora socialis. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments. Both compounds showed potent inhibitory activity against tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin cell signalling. Compounds 1 and 2 had IC50 values of 3.7 and 1.7 uM, respectively.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeWashington, DC
dc.publisher.urihttp://pubs.acs.org/journals/jnprdf/index.html
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom1790
dc.relation.ispartofpageto1792
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume70
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleVanillic Acid Derivatives from the Green Algae Cladophora socialis As Potent Protein Tyrosine Phosphatase 1B Inhibitors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2007 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page after publication. Use hypertext link above to access the ACS website.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorAvery, Vicky M.
gro.griffith.authorFeng, Yun J.


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