NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids

Barnham, KJ; BernersPrice, SJ; Guo, ZJ; Murdoch, PD; Sadler, PJ

doi:10.1007/978-1-4899-0218-4_1

Author(s)

Barnham, KJ

BernersPrice, SJ

Guo, ZJ

Murdoch, PD

Sadler, PJ

Griffith University Author(s)

Berners-Price, Sue J.

Year published

1996

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Abstract

In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.
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Conference Title

PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2

DOI

https://doi.org/10.1007/978-1-4899-0218-4_1

Subject

Other chemical sciences not elsewhere classified

Publication URI

http://hdl.handle.net/10072/179446

Collection

Conference outputs