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  • NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids

    Author(s)
    Barnham, KJ
    BernersPrice, SJ
    Guo, ZJ
    Murdoch, PD
    Sadler, PJ
    Griffith University Author(s)
    Berners-Price, Sue J.
    Year published
    1996
    Metadata
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    Abstract
    In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.
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    Conference Title
    PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2
    DOI
    https://doi.org/10.1007/978-1-4899-0218-4_1
    Subject
    Other chemical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/179446
    Collection
    • Conference outputs

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