NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids
Author(s)
Barnham, KJ
BernersPrice, SJ
Guo, ZJ
Murdoch, PD
Sadler, PJ
Griffith University Author(s)
Year published
1996
Metadata
Show full item recordAbstract
In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.
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Conference Title
PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2
Subject
Other chemical sciences not elsewhere classified