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dc.contributor.authorWilkinson, Brendan L
dc.contributor.authorBornaghi, Laurent F
dc.contributor.authorWright, Anthony D
dc.contributor.authorHouston, Todd A
dc.contributor.authorPoulsen, Sally-Ann
dc.date.accessioned2017-05-03T11:45:27Z
dc.date.available2017-05-03T11:45:27Z
dc.date.issued2007
dc.date.modified2009-12-08T07:54:23Z
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2006.11.079
dc.identifier.urihttp://hdl.handle.net/10072/17944
dc.description.abstractSince the introduction of prontosil over 70 years ago, sulfa drugs have been widely used to treat a broad spectrum of infectious microorganisms. The bioactive component of prontosil, sulfanilamide (1), inhibits 6-hydroxymethyl-7,8-dihydropteroate synthase (DHPS) selectively limiting folate synthesis in prokaryotes and lower eukaryotes thus disrupting the integrity of their DNA synthesis.1 The evolution of drug resistance in infectious microorganisms underpins an immense and ongoing need for new therapies to treat infectious diseases. The identification of new and novel chemical entities with activity against cells infected with the microorganism is a crucial component of this anti-infective drug development pathway.2 Although sulfonamides are not specifically incorporated into current tuberculosis treatment, many sulfur-3,4, sulfonyl-4,5,6, and sulfonamide-containing7,8 compounds are active against mycobacteria. This prompted us to screen our growing library of triazole-based sulfonamides (e.g.-2) for antimycobacterial activity. Herein we report identification of a novel bis-sulfonamide with antimicrobial activity against Mycobacterium smegmatis that is relatively inert toward common bacterial and fungal strains.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon Press
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.sciencedirect.com/science/journal/0960894X
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1355
dc.relation.ispartofpageto1357
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.titleAnti-mycobacterial activity of a bis-sulfonamide
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorPoulsen, Sally-Ann
gro.griffith.authorHouston, Todd A.


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