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dc.contributor.authorWilkinson, Brendanen_US
dc.contributor.authorBornaghi, Laurenten_US
dc.contributor.authorD. Wright, Anthonyen_US
dc.contributor.authorHouston, Todden_US
dc.contributor.authorPoulsen, Sally-Annen_US
dc.date.accessioned2017-05-03T11:45:27Z
dc.date.available2017-05-03T11:45:27Z
dc.date.issued2007en_US
dc.date.modified2009-12-08T07:54:23Z
dc.identifier.issn0960894Xen_US
dc.identifier.doi10.1016/j.bmcl.2006.11.079en_AU
dc.identifier.urihttp://hdl.handle.net/10072/17944
dc.description.abstractSince the introduction of prontosil over 70 years ago, sulfa drugs have been widely used to treat a broad spectrum of infectious microorganisms. The bioactive component of prontosil, sulfanilamide (1), inhibits 6-hydroxymethyl-7,8-dihydropteroate synthase (DHPS) selectively limiting folate synthesis in prokaryotes and lower eukaryotes thus disrupting the integrity of their DNA synthesis.1 The evolution of drug resistance in infectious microorganisms underpins an immense and ongoing need for new therapies to treat infectious diseases. The identification of new and novel chemical entities with activity against cells infected with the microorganism is a crucial component of this anti-infective drug development pathway.2 Although sulfonamides are not specifically incorporated into current tuberculosis treatment, many sulfur-3,4, sulfonyl-4,5,6, and sulfonamide-containing7,8 compounds are active against mycobacteria. This prompted us to screen our growing library of triazole-based sulfonamides (e.g.-2) for antimycobacterial activity. Herein we report identification of a novel bis-sulfonamide with antimicrobial activity against Mycobacterium smegmatis that is relatively inert toward common bacterial and fungal strains.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherPergamon Pressen_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/0960894Xen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1355en_US
dc.relation.ispartofpageto1357en_US
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.ispartofvolume17en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250302en_US
dc.titleAnti-mycobacterial activity of a bis-sulfonamideen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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