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dc.contributor.authorE. Weynants, Vincenten_US
dc.contributor.authorM. Feron, Christianeen_US
dc.contributor.authorK.Goraj, Karineen_US
dc.contributor.authorP. Bos, Martineen_US
dc.contributor.authorDenoel, Philippeen_US
dc.contributor.authorG. Verlant, Vincenten_US
dc.contributor.authorTommassen, Janen_US
dc.contributor.authorPeak, Ianen_US
dc.contributor.authorJudd, Ralphen_US
dc.contributor.authorJennings, Michaelen_US
dc.contributor.authorPoolman, Janen_US
dc.contributor.editorAlison D. O'Brienen_US
dc.date.accessioned2017-04-24T09:17:17Z
dc.date.available2017-04-24T09:17:17Z
dc.date.issued2007en_US
dc.date.modified2014-02-28T02:57:46Z
dc.identifier.issn00199567en_US
dc.identifier.doi10.1128/IAI.00411-07en_US
dc.identifier.urihttp://hdl.handle.net/10072/18237
dc.description.abstractNeisseria meningitidis serogroup B is a major cause of bacterial meningitis in younger populations. The available vaccines are based on outer membrane vesicles obtained from wild-type strains. In children less than 2 years old they confer protection only against strains expressing homologous PorA, a major, variable outer membrane protein (OMP). We genetically modified a strain in order to eliminate PorA and to overproduce one or several minor and conserved OMPs. Using a mouse model mimicking children's PorA-specific bactericidal activity, it was demonstrated that overproduction of more than one minor OMP is required to elicit antibodies able to induce complement-mediated killing of strains expressing heterologous PorA. It is concluded that a critical density of bactericidal antibodies needs to be reached at the surface of meningococci to induce complement-mediated killing. With minor OMPs, this threshold is reached when more than one antigen is targeted, and this allows cross-protection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeWashington, DCen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom5434en_US
dc.relation.ispartofpageto5442en_US
dc.relation.ispartofissue11en_US
dc.relation.ispartofjournalInfection and Immunityen_US
dc.relation.ispartofvolume75en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode320401en_US
dc.subject.fieldofresearchcode321206en_US
dc.titleAdditive and synergistic bactericidal activity of antibodies directed against minor outer membrane proteins of Neisseria meningitidisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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