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dc.contributor.authorvon Itzstein, Marken_US
dc.date.accessioned2017-04-24T07:56:32Z
dc.date.available2017-04-24T07:56:32Z
dc.date.issued2007en_US
dc.date.modified2009-10-19T05:24:14Z
dc.identifier.issn14741776en_US
dc.identifier.doi10.1038/nrd2400en_AU
dc.identifier.urihttp://hdl.handle.net/10072/18269
dc.description.abstractThe threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At present, two inhibitors of sialidase (also known as neuraminidase), a viral enzyme that has a key role in the life cycle of influenza viruses, would be the mainstay of pharmacological strategies in the event of such a pandemic. This article provides a historical perspective on the discovery and development of these drugs - zanamivir and oseltamivir - and highlights the value of structure-based drug design in this process.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUKen_US
dc.publisher.urihttp://www.nature.com/nrd/index.htmlen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom967en_US
dc.relation.ispartofpageto974en_US
dc.relation.ispartofjournalNature Reviews Drug Discoveryen_US
dc.relation.ispartofvolume6en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250699en_US
dc.subject.fieldofresearchcode250301en_US
dc.titleThe war against influenza: discovery and development of sialidase inhibitorsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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