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dc.contributor.authorTindal1159448, DavidDNUen_US
dc.contributor.authorDyason, Jeffreyen_US
dc.contributor.authorThomson, Robinen_US
dc.contributor.authorSuzuki, Takashien_US
dc.contributor.authorUeyama, Hirooen_US
dc.contributor.authorKuwahara, Yohtaen_US
dc.contributor.authorMaki, Naoyoshien_US
dc.contributor.authorSuzuki, Yasuoen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.editorD.L. Boger, L. Ghosez and M. Shibasakien_US
dc.date.accessioned2017-04-24T07:56:33Z
dc.date.available2017-04-24T07:56:33Z
dc.date.issued2007en_US
dc.date.modified2009-10-19T05:24:18Z
dc.identifier.issn0960894Xen_US
dc.identifier.doi10.1016/j.bmcl.2006.12.105en_AU
dc.identifier.urihttp://hdl.handle.net/10072/18270
dc.description.abstractThe X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3-30 卮 This is comparable or improved activity compared to the parent 4-hydroxy compound.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherPergamon Pressen_US
dc.publisher.placeOxford, UKen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1655en_US
dc.relation.ispartofpageto1658en_US
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.ispartofvolume17en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250699en_US
dc.subject.fieldofresearchcode250301en_US
dc.titleSynthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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