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dc.contributor.authorE. Wickham, Mark
dc.contributor.authorBrown, Nathaniel
dc.contributor.authorProvias, John
dc.contributor.authorBrett Finlay, B.
dc.contributor.authorK. Coombes, Brian
dc.date.accessioned2017-05-03T12:25:14Z
dc.date.available2017-05-03T12:25:14Z
dc.date.issued2007
dc.identifier.issn1471-2334
dc.identifier.doi10.1186/1471-2334-7-65
dc.identifier.urihttp://hdl.handle.net/10072/18271
dc.description.abstractBACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS: Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. RESULTS: We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. CONCLUSION: This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent775903 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeLondon
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofjournalBMC Infectious Diseases
dc.relation.ispartofvolume7
dc.rights.retentionN
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode4206
dc.titleOral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 65.
gro.rights.copyright© 2007 Wickham et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2015-05-12T02:03:38Z
gro.hasfulltextFull Text
gro.griffith.authorBrown, Nathaniel F.


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