dc.contributor.author | E. Wickham, Mark | |
dc.contributor.author | Brown, Nathaniel | |
dc.contributor.author | Provias, John | |
dc.contributor.author | Brett Finlay, B. | |
dc.contributor.author | K. Coombes, Brian | |
dc.date.accessioned | 2017-05-03T12:25:14Z | |
dc.date.available | 2017-05-03T12:25:14Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1471-2334 | |
dc.identifier.doi | 10.1186/1471-2334-7-65 | |
dc.identifier.uri | http://hdl.handle.net/10072/18271 | |
dc.description.abstract | BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS: Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. RESULTS: We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. CONCLUSION: This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 775903 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central | |
dc.publisher.place | London | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1 | |
dc.relation.ispartofpageto | 6 | |
dc.relation.ispartofjournal | BMC Infectious Diseases | |
dc.relation.ispartofvolume | 7 | |
dc.rights.retention | N | |
dc.subject.fieldofresearch | Microbiology | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Medical microbiology | |
dc.subject.fieldofresearch | Public health | |
dc.subject.fieldofresearchcode | 3107 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3207 | |
dc.subject.fieldofresearchcode | 4206 | |
dc.title | Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/2.0 | |
gro.description.notepublic | Page numbers are not for citation purposes. Instead, this article has the unique article number of 65. | |
gro.rights.copyright | © 2007 Wickham et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
gro.date.issued | 2015-05-12T02:03:38Z | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Brown, Nathaniel F. | |