Show simple item record

dc.contributor.authorCui, Xiaoying
dc.contributor.authorMcGrath, John J
dc.contributor.authorBurne, Thomas HJ
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorEyles, Darryl W
dc.date.accessioned2017-05-03T11:32:34Z
dc.date.available2017-05-03T11:32:34Z
dc.date.issued2007
dc.date.modified2009-09-22T05:51:09Z
dc.identifier.issn0736-5748
dc.identifier.doi10.1016/j.ijdevneu.2007.03.006
dc.identifier.urihttp://hdl.handle.net/10072/18512
dc.description.abstractEvidence is accumulating that normal levels of vitamin D are important for brain development. Vitamin D acts as an anti-proliferative agent in a wide variety of tissues and developmental vitamin D (DVD) deficiency has been shown to alter brain structure and function. The aim of this study was to investigate the effect of DVD deficiency on neuroprogenitor formation in the neonatal brain. We show that DVD deficiency increased the number of neurospheres formed in cultures from the neonatal subventricular zone. Exogenous vitamin D added to the culture medium reduced neurosphere number in control but not DVD cultures. We show the receptor for vitamin D is concentrated in the subventricular zone and is also present in cultured neurospheres prepared from this region. These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAmsterdam
dc.publisher.urihttp://www.sciencedirect.com/science/journal/07365748
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom227
dc.relation.ispartofpageto232
dc.relation.ispartofissue4
dc.relation.ispartofjournalInternational Journal of Developmental Neuroscience
dc.relation.ispartofvolume25
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleMaternal vitamin D depletion alters neurogenesis in the developing rat brain
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record