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  • Systems biology of transcription control in macrophages

    Author(s)
    Ravasi, Timothy
    Wells, Christine
    A. Hume, David
    Griffith University Author(s)
    Wells, Christine
    Year published
    2007
    Metadata
    Show full item record
    Abstract
    The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genome-scale analysis of the transcriptome, and transcription initiation has enabled the construction of predictive models of transcription control in macrophages that ...
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    The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genome-scale analysis of the transcriptome, and transcription initiation has enabled the construction of predictive models of transcription control in macrophages that identify the points of control (the major nodes of networks) and the ways in which they interact. BioEssays 29:1215-1226, 2007. 頲007 Wiley Periodicals, Inc.
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    Journal Title
    BioEssays
    Volume
    29
    Issue
    12
    Publisher URI
    https://onlinelibrary.wiley.com/doi/10.1002/bies.20683
    DOI
    https://doi.org/10.1002/bies.20683
    Copyright Statement
    © 2007 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
    Subject
    History and Archaeology
    Biological Sciences
    Medical and Health Sciences
    Psychology and Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/18517
    Collection
    • Journal articles

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