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dc.contributor.authorZhao, Yan
dc.contributor.authorZhao, Xiujuan
dc.contributor.authorYang, Baofeng
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorWu, Kun
dc.date.accessioned2017-05-03T12:46:25Z
dc.date.available2017-05-03T12:46:25Z
dc.date.issued2007
dc.date.modified2009-09-09T07:17:45Z
dc.identifier.issn0304-3835
dc.identifier.doi10.1016/j.canlet.2006.05.015
dc.identifier.urihttp://hdl.handle.net/10072/18794
dc.description.abstractGastric neoplastic disease is one of the most frequent causes of cancer-associated deaths with poor prognosis. Here we studied the effect of the redox-silent analogue a-tocopheryl succinate (a-TOS), a strong apoptogen and anti-cancer agent, on the gastric cancer cell line SGC-7901. a-TOS inhibited proliferation of the cells and induced their apoptosis in a concentration- and time-dependent manner, while succinate or a-tocopherol showed no effect. The effect of a-TOS was modulated by components of the MAPK signaling network, including ERK1/2 and c-Jun N-terminal kinase (JNK), but not p38. Activation of ERK1/2 occurred early and increased until 12 h, coinciding with an in crease in apoptosis in the cells, after which it dropped abruptly, while activation of JNK rose steadily, reaching a plateau at 12 h of a-TOS treatment. The effects of ERK1/2 and JNK on the apoptosis outcome are transmitted via c-Jun, since transfection of the cells with c-Jun antisense oligodeoxynucleotide inhibited a-TOS-induced apoptosis. We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by a-TOS.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherElsevier Ireland Ltd.
dc.publisher.placeIreland
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#description
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom345
dc.relation.ispartofpageto352
dc.relation.ispartofissue2
dc.relation.ispartofjournalCancer Letters
dc.relation.ispartofvolume247
dc.rights.retentionY
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.titleα-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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