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dc.contributor.authorZhao, Yanen_US
dc.contributor.authorZhao, Xiujuanen_US
dc.contributor.authorYang, Baofengen_US
dc.contributor.authorNeuzil, Jirien_US
dc.contributor.authorWu, Kunen_US
dc.date.accessioned2017-05-03T12:46:25Z
dc.date.available2017-05-03T12:46:25Z
dc.date.issued2007en_US
dc.date.modified2009-09-09T07:17:45Z
dc.identifier.issn03043835en_US
dc.identifier.doi10.1016/j.canlet.2006.05.015en_AU
dc.identifier.urihttp://hdl.handle.net/10072/18794
dc.description.abstractGastric neoplastic disease is one of the most frequent causes of cancer-associated deaths with poor prognosis. Here we studied the effect of the redox-silent analogue a-tocopheryl succinate (a-TOS), a strong apoptogen and anti-cancer agent, on the gastric cancer cell line SGC-7901. a-TOS inhibited proliferation of the cells and induced their apoptosis in a concentration- and time-dependent manner, while succinate or a-tocopherol showed no effect. The effect of a-TOS was modulated by components of the MAPK signaling network, including ERK1/2 and c-Jun N-terminal kinase (JNK), but not p38. Activation of ERK1/2 occurred early and increased until 12 h, coinciding with an in crease in apoptosis in the cells, after which it dropped abruptly, while activation of JNK rose steadily, reaching a plateau at 12 h of a-TOS treatment. The effects of ERK1/2 and JNK on the apoptosis outcome are transmitted via c-Jun, since transfection of the cells with c-Jun antisense oligodeoxynucleotide inhibited a-TOS-induced apoptosis. We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by a-TOS.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Ireland Ltd.en_US
dc.publisher.placeIrelanden_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom345en_US
dc.relation.ispartofpageto352en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalCancer Lettersen_US
dc.relation.ispartofvolume247en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270106en_US
dc.titleα-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manneren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyright© 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2007
gro.hasfulltextNo Full Text


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