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dc.contributor.authorRickard, Claireen_US
dc.contributor.authorO'Meara, Peteren_US
dc.contributor.authorMcGrail, Matthewen_US
dc.contributor.authorGarner, Daviden_US
dc.contributor.authorMcLean, Alanen_US
dc.contributor.authorLievre, Peteren_US
dc.date.accessioned2017-05-03T15:24:58Z
dc.date.available2017-05-03T15:24:58Z
dc.date.issued2007en_US
dc.date.modified2008-05-16T03:44:46Z
dc.identifier.issn07356757en_US
dc.identifier.doi10.1016/j.ajem.2007.02.027en_AU
dc.identifier.urihttp://hdl.handle.net/10072/18847
dc.description.abstractStudy Objective The objective of the study was to compare intranasal fentanyl (INF) with intravenous morphine (IVM) for prehospital analgesia. Methods This was a randomized, controlled, open-label trial. Consecutive adult patients (n = 258) requiring analgesia (Verbal Rating Score [VRS] >2/10 noncardiac or >5/10 cardiac) were recruited. Patients received INF 180 姠ᠲ doses of 60 姠at =5-minute intervals or IVM 2.5 to 5 mg ᠲ doses of 2.5 to 5 mg at =5-minute intervals. The end point was the difference in baseline/destination VRS. Results Groups were equivalent (P = not significant) for baseline VRS [mean (SD): INF 8.3 (1.7), IVM 8.1 (1.6)] and minutes to destination [mean (SD): INF 27.2 (15.5), IVM 30.6 (19.1)]. Patients had a mean (95% confidence interval) VRS reduction as follows: INF 4.22 (3.74-4.71), IVM 3.57 (3.10-4.03); P = .08. Higher baseline VRS (P < .001), no methoxyflurane use (P < .01), and back pain (P = .02) predicted VRS reduction. Safety and acceptability were comparable. Conclusions There was no significant difference in the effectiveness of INF and IVM for prehospital analgesia.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent105302 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/07356757en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom911en_US
dc.relation.ispartofpageto917en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalAmerican Journal of Emergency Medicineen_US
dc.relation.ispartofvolume25en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode321099en_US
dc.subject.fieldofresearchcode321001en_US
dc.subject.fieldofresearchcode321103en_US
dc.titleA randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital settingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Nursing and Midwiferyen_US
gro.rights.copyrightCopyright 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2007
gro.hasfulltextFull Text


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