α-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
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Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with greek small letter alpha-tocopheryl succinate (greek small letter alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that greek small letter alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling.
Copyright 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.