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dc.contributor.authorNeuzil, Jiri
dc.contributor.authorSwettenham, Emma
dc.contributor.authorWang, Xiu-Fang
dc.contributor.authorDong, Lan-Feng
dc.contributor.authorStapelberg, Michael
dc.contributor.editorFelix Wieland
dc.date.accessioned2017-05-03T15:05:22Z
dc.date.available2017-05-03T15:05:22Z
dc.date.issued2007
dc.date.modified2009-09-09T07:16:17Z
dc.identifier.issn0014-5793
dc.identifier.doi10.1016/j.febslet.2007.08.051
dc.identifier.urihttp://hdl.handle.net/10072/18957
dc.description.abstractMalignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with greek small letter alpha-tocopheryl succinate (greek small letter alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that greek small letter alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeGermany
dc.publisher.urihttps://febs.onlinelibrary.wiley.com/loi/18733468/year/2007
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4611
dc.relation.ispartofpageto4615
dc.relation.ispartofjournalFEBS Letters
dc.relation.ispartofvolume581
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3104
dc.titleα-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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