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dc.contributor.authorMcCabe, Michael
dc.contributor.authorMaguire, David
dc.date.accessioned2017-05-03T12:56:12Z
dc.date.available2017-05-03T12:56:12Z
dc.date.issued2007
dc.identifier.issn00652598
dc.identifier.doi10.1007/978-0-387-71764-7_12
dc.identifier.urihttp://hdl.handle.net/10072/19101
dc.description.abstractWyman's equation of 1966 1 describes the facilitation of flux of a reversibly bound substrate such as oxygen, consequent on the translational diffusion of the binding protein (the carrier). While Wyman's equation 1, or some modification of it such as that by Murray 2, may provide a realistic description of the flux of oxygen through a dilute solution of haemoglobin (see also Wittenburg 3, 4), it is unlikely to be the complete explanation, nor even the basis, for oxygen transport through the intact red cell. The mature erythrocyte contains approximately 350g/l haemoglobin, and while this suggests that only 35% of the available water volume is actually occupied by the protein, the remaining 65% is unavailable for protein translational diffusion due to the mutual exclusion of the haemoglobin molecules. For this reason we have examined other possible mechanisms whereby haemoglobin may facilitate the translational diffusion of oxygen within the erythrocyte. Possible alternatives include rotational diffusion by the haemoglobins, intracellular shuffling of haemoglobins due to shape changes by the erythrocyte, and haemoglobin rotations and oxygen exchange consequent on the charge change which accompanies substration and desubstration of the haemoglobin molecule. Finally the dipole interactions are shown to generate significant intermolecular attractions between adjacent haemoglobins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer New York LLC
dc.publisher.placeUnited States
dc.publisher.urihttp://dx.doi.org/10.1007/978-0-387-71764-7
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom87
dc.relation.ispartofpageto92
dc.relation.ispartofjournalAdvances in Experimental Medicine and Biology
dc.relation.ispartofvolume599
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode11
dc.titleWyman's Equation and Oxygen Flux through the Red Cell
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.date.issued2015-02-02T04:17:49Z
gro.hasfulltextNo Full Text
gro.griffith.authorMaguire, David J.
gro.griffith.authorMcCabe, Michael


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