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  • Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria

    Author(s)
    Neuzil, Jiri
    Dong, Lan-Feng
    Ramanathapuram, Lalitha
    Hahn, Tobias
    Chladova, Miroslava
    Wang, Xiu-Fang
    Zobalova, Renata
    Prochazka, Lubomir
    Gold, Mikhal
    Freeman, Ruth
    Turanek, Jaroslav
    Akporiaye, Emmanuel T
    Dyason, Jeffrey C
    Ralph, Stephen J
    Griffith University Author(s)
    Neuzil, Jiri
    Ralph, Stephen J.
    Year published
    2007
    Metadata
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    Abstract
    Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and often lie downstream from the initial actions of anti-cancer drugs. Unlike the tumour suppressor gene encoding p53 that is notoriously prone to inactivating mutations but whose function is essential for induction of apoptosis by DNA-targeting agents (such as doxorubicin or 5-fluorouracil), mitochondria present targets that are not so compromised by genetic mutation and whose targeting overcomes problems with mutations of upstream ...
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    Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and often lie downstream from the initial actions of anti-cancer drugs. Unlike the tumour suppressor gene encoding p53 that is notoriously prone to inactivating mutations but whose function is essential for induction of apoptosis by DNA-targeting agents (such as doxorubicin or 5-fluorouracil), mitochondria present targets that are not so compromised by genetic mutation and whose targeting overcomes problems with mutations of upstream targets such as p53. We have recently proposed a novel class of anti-cancer agents, mitocans that exert their anti-cancer activity by destabilising mitochondria, promoting the selective induction of apoptotic death in tumour cells. In this communication, we review recent findings on mitocans and propose a common basis for their mode of action in inducing apoptosis of cancer cells. We use as an example the analogues of vitamin E that are proving to be cancer cell-specific and may soon be developed into efficient anti-cancer drugs.
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    Journal Title
    Molecular Aspects of Medicine
    Volume
    28
    Issue
    5-6
    Publisher URI
    http://www.elsevier.com/locate/mam
    DOI
    https://doi.org/10.1016/j.mam.2007.02.003
    Copyright Statement
    © 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/19192
    Collection
    • Journal articles

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