• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Book chapters
    • View Item
    • Home
    • Griffith Research Online
    • Book chapters
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Oxygen Sensors of the Peripheral and Central Nervous Systems

    Thumbnail
    View/Open
    50135_1.pdf (305.4Kb)
    Author(s)
    Renshaw, GMC
    Nikinmaa, M
    Griffith University Author(s)
    Renshaw, Gillian M.
    Year published
    2007
    Metadata
    Show full item record
    Abstract
    Neural systems exposed to diminished oxygen availability have a compromised metabolism that leads to pathophysiological changes or neuronal death, depending on the severity and duration of oxygen deprivation. A distributed network of oxygen sensors responds to protect cells by slowing or ameliorating pathophysiological changes and forestalling neuronal death via short-term or long-term changes involving gene expression and the modification of sensors and effectors. In mammalian systems such protective changes are not sufficient to prevent damage under extreme conditions, unlike some hypoxia and anoxia-tolerant vertebrates ...
    View more >
    Neural systems exposed to diminished oxygen availability have a compromised metabolism that leads to pathophysiological changes or neuronal death, depending on the severity and duration of oxygen deprivation. A distributed network of oxygen sensors responds to protect cells by slowing or ameliorating pathophysiological changes and forestalling neuronal death via short-term or long-term changes involving gene expression and the modification of sensors and effectors. In mammalian systems such protective changes are not sufficient to prevent damage under extreme conditions, unlike some hypoxia and anoxia-tolerant vertebrates which demonstrate oxygen-dependent, reversible reprogramming to protect vital organs such as the brain and heart. This chapter examines (1) the nature of the signal for oxygen sensors; (2) the molecules used to sense oxygen; (3) how the primary signal is generated, converted, and used in an oxygen-dependent manner; (4) how effector systems function in different cell types; and (5) how oxygen sensing pathways are interconnected to more general protective stress responses which confer cross protection for a number of physiological stressors. While future therapies may focus on the activation of hypoxia inducible factor (HIF) and its downstream gene products, selected gene products could be administered to reduce neuronal loss and improve recovery after acute insults due to ischemic events and degenerative diseases of the brain and retina. Activation of neuroprotective pathways by oxygen sensors and other physiological stressors could be used as pre-treatment to minimize neurotrauma associated with neurosurgical procedures and as an ancillary treatment during early stages of rehabilitation.
    View less >
    Book Title
    Handbook of Neurochemistry and Molecular Neurobiology: sensory neurochemistry
    Publisher URI
    http://www.springer.com/biomed/neuroscience/book/978-0-387-30349-9
    Copyright Statement
    © 2007 Springer. The attached file is reproduced here in accordance with the copyright policy of the publisher. The original publication is available at www.springerlink.com
    Publication URI
    http://hdl.handle.net/10072/19281
    Collection
    • Book chapters

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander