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dc.contributor.authorLiu, Jianwen
dc.contributor.authorLewohl, Joanne M
dc.contributor.authorHarris, R Adron
dc.contributor.authorDodd, Peter R
dc.contributor.authorMayfield, R Dayne
dc.date.accessioned2017-05-03T11:36:52Z
dc.date.available2017-05-03T11:36:52Z
dc.date.issued2007
dc.identifier.issn0145-6008
dc.identifier.doi10.1111/j.1530-0277.2007.00444.x
dc.identifier.urihttp://hdl.handle.net/10072/19341
dc.description.abstractBackground: Cirrhosis is the result of chronic liver disease that causes scarring and dysfunction of the liver. The disease is a common concomitant condition resulting from sustained exposure to alcohol. Heavy alcohol use results in brain damage that is generally more severe in cirrhotic compared with noncirrhotic alcoholics. We examined, at the cellular level, gene expression in the frontal cortex of cirrhotic alcoholics. Methods: Gene expression profiles were compared between cirrhotic and noncirrhotic alcoholics using 47,000 element cDNA microarrays. Results: Widespread differences in transcriptome patterns were observed in cirrhotic compared with noncirrhotic alcoholics and these differences in gene expression accurately distinguished cirrhotic from noncirrhotic alcoholics. Functionally related groups of genes were identified that are involved in cell adhesion, mitochondrial function, synaptic transmission, apoptosis, and cell proliferation. Both astrocytes and neuronal cells were affected at the transcriptional level. The regulated genes are involved in neurite growth, neuronal cell adhesion, synaptic vesicle release, and postsynaptic neurotransmission. Conclusions: These changes in the transcriptome likely contribute to the more severe brain dysfunction in cirrhotic alcoholics.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeOxford, England
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1460
dc.relation.ispartofpageto1466
dc.relation.ispartofissue9
dc.relation.ispartofjournalAlcoholism: Clinical and Experimental Research
dc.relation.ispartofvolume31
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.titleAltered Gene Expression Profiles in the Frontal Cortex of Cirrhotic Alcoholics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-03T03:03:31Z
gro.hasfulltextNo Full Text
gro.griffith.authorLewohl, Joanne M.


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