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  • Dendritic Cell Immunotherapy for Stage IV Melanoma

    Author(s)
    O'Rourke, Michael GE
    Johnson, Maree K
    Lanagan, Catherine M
    See, Janet L
    O'Connor, Linda E
    Slater, Gregory J
    Thomas, David
    Lopez, Jose Alejandro
    Martinez, Nathan R
    Ellem, Kay AO
    Schmidt, Christopher W
    Griffith University Author(s)
    Lopez Ramirez, Alejandro
    Year published
    2007
    Metadata
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    Abstract
    Active boosting of the antitumour immune response of patients with solid malignancies has been tested in a large number of trials. Isolated complete clinical responses have been reported, however, they have not been replicated in subsequent studies. We recently reported objective clinical responses to a dendritic cell/irradiated autologous tumour cell 'vaccine' in patients with distant metastatic (stage IV) melanoma. Here we describe our experience in a second cohort of patients with stage IV melanoma, using this dendritic cell-based immunotherapy in a cryopreserved format. Of 46 patients enroled into the study, three had ...
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    Active boosting of the antitumour immune response of patients with solid malignancies has been tested in a large number of trials. Isolated complete clinical responses have been reported, however, they have not been replicated in subsequent studies. We recently reported objective clinical responses to a dendritic cell/irradiated autologous tumour cell 'vaccine' in patients with distant metastatic (stage IV) melanoma. Here we describe our experience in a second cohort of patients with stage IV melanoma, using this dendritic cell-based immunotherapy in a cryopreserved format. Of 46 patients enroled into the study, three had complete remission of all detectable disease, and a further three had partial clinical responses. These data confirm that dendritic cell-based immunotherapy has potential as a therapy in a limited number of patients with stage IV melanoma. To our knowledge, this is the first demonstration that cryopreserved dendritic cells can elicit complete clinical responses in patients with advanced cancer. Our observations support randomized controlled trials to validate the findings.
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    Journal Title
    Melanoma Research
    Volume
    17
    Issue
    5
    Publisher URI
    https://journals.lww.com/melanomaresearch/Fulltext/2007/10000/Dendritic_cell_immunotherapy_for_stage_IV_melanoma.7.aspx
    DOI
    https://doi.org/10.1097/CMR.0b013e3282c3a73b
    Copyright Statement
    © 2007 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/19484
    Collection
    • Journal articles

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