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dc.contributor.authorO'Rourke, Michael GE
dc.contributor.authorJohnson, Maree K
dc.contributor.authorLanagan, Catherine M
dc.contributor.authorSee, Janet L
dc.contributor.authorO'Connor, Linda E
dc.contributor.authorSlater, Gregory J
dc.contributor.authorThomas, David
dc.contributor.authorLopez, Jose Alejandro
dc.contributor.authorMartinez, Nathan R
dc.contributor.authorEllem, Kay AO
dc.contributor.authorSchmidt, Christopher W
dc.date.accessioned2017-05-03T14:18:51Z
dc.date.available2017-05-03T14:18:51Z
dc.date.issued2007
dc.date.modified2009-12-08T07:54:28Z
dc.identifier.issn0960-8931
dc.identifier.doi10.1097/CMR.0b013e3282c3a73b
dc.identifier.urihttp://hdl.handle.net/10072/19484
dc.description.abstractActive boosting of the antitumour immune response of patients with solid malignancies has been tested in a large number of trials. Isolated complete clinical responses have been reported, however, they have not been replicated in subsequent studies. We recently reported objective clinical responses to a dendritic cell/irradiated autologous tumour cell 'vaccine' in patients with distant metastatic (stage IV) melanoma. Here we describe our experience in a second cohort of patients with stage IV melanoma, using this dendritic cell-based immunotherapy in a cryopreserved format. Of 46 patients enroled into the study, three had complete remission of all detectable disease, and a further three had partial clinical responses. These data confirm that dendritic cell-based immunotherapy has potential as a therapy in a limited number of patients with stage IV melanoma. To our knowledge, this is the first demonstration that cryopreserved dendritic cells can elicit complete clinical responses in patients with advanced cancer. Our observations support randomized controlled trials to validate the findings.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.publisher.urihttps://journals.lww.com/melanomaresearch/Fulltext/2007/10000/Dendritic_cell_immunotherapy_for_stage_IV_melanoma.7.aspx
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom316
dc.relation.ispartofpageto322
dc.relation.ispartofissue5
dc.relation.ispartofjournalMelanoma Research
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleDendritic Cell Immunotherapy for Stage IV Melanoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2007 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorLopez Ramirez, Alejandro


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    Contains articles published by Griffith authors in scholarly journals.

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