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dc.contributor.authorPinzon-Charry, A
dc.contributor.authorHo, CSK
dc.contributor.authorMaxwell, T
dc.contributor.authorMcGuckin, MA
dc.contributor.authorSchmidt, C
dc.contributor.authorFurnival, C
dc.contributor.authorPyke, CM
dc.contributor.authorLopez, JA
dc.date.accessioned2017-09-06T00:17:42Z
dc.date.available2017-09-06T00:17:42Z
dc.date.issued2007
dc.date.modified2009-12-08T07:55:54Z
dc.identifier.issn0007-0920
dc.identifier.doi10.1038/sj.bjc.6604018
dc.identifier.urihttp://hdl.handle.net/10072/19485
dc.description.abstractThe generation of antitumour immunity depends on the nature of dendritic cell (DC)-tumour interactions. These have been studied mostly by using in vitro-derived DC which may not reflect the natural biology of DC in vivo. In breast cancer, only one report has compared blood DC at different stages and no longitudinal evaluation has been performed. Here we conducted three cross-sectional and one one-year longitudinal assessments of blood DC in patients with early (stage I/II, n=137) and advanced (stage IV, n=36) disease compared to healthy controls (n=66). Patients with advanced disease exhibit markedly reduced blood DC counts at diagnosis. Patients with early disease show minimally reduced counts at diagnosis but a prolonged period (1 year) of marked DC suppression after tumour resection. While differing in frequency, DC from both patients with early and advanced disease exhibit reduced expression of CD86 and HLA-DR and decreased immunostimulatory capacities. Finally, by comparing a range of clinically available maturation stimuli, we demonstrate that conditioning with soluble CD40L induces the highest level of maturation and improved T-cell priming. We conclude that although circulating DC are compromised by loco-regional and systemic breast cancer, they respond vigorously to ex vivo conditioning, thus enhancing their immunostimulatory capacity and potential for immunotherapy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherNature Publishing Group
dc.publisher.placeLondon, UK
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1251
dc.relation.ispartofpageto1259
dc.relation.ispartofissue9
dc.relation.ispartofjournalBritish Journal of Cancer
dc.relation.ispartofvolume97
dc.rights.retentionY
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1117
dc.titleNumerical and functional defects of blood dendritic cells in early- and late-stage breast cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2007. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
gro.date.issued2007
gro.hasfulltextFull Text
gro.griffith.authorLopez Ramirez, Alejandro
gro.griffith.authorPinzon-Charry, Alberto


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