Guidelines for the Diagnosis and Management of Familial Long QT Syndrome
Author(s)
Skinner, Jon R.
Semsarian, Chris
Fatkin, Diane
Sullivan, David
Ades, Lesley
Hamilton-Craig, Ian
Ingles, Jodie
French, John
Davis, Andrew
Weintraub, Robert
Crawford, Jackie
Macciocca, Ivan
Vohra, Jitu
Horowitz, John
Jeremy, Richmond
Richmond, David
Kirk, Edwin
Ryan, Mark
West, Malcolm
Atherton, John
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
Definition and Prevalence
Long QT syndrome (LQTS) is a familial condition causing syncope and sudden death through rapid ventricular tachycardia (torsade de pointes), which can deteriorate to ventricular fibrillation, in otherwise fit and healthy young people. Prevalence is at least 1 in 5000 and may be up to 1 in 1000. Clinical diagnosis is made from a combination of suspicious history, family history and the 12 lead ECG, which typically reveals a heart-rate corrected QT interval (QT//R–R interval = QTc) of greater than 0.46 s in women and 0.45 s in men. Exercise testing is often helpful in making the diagnosis.
Clinical ...
View more >Definition and Prevalence Long QT syndrome (LQTS) is a familial condition causing syncope and sudden death through rapid ventricular tachycardia (torsade de pointes), which can deteriorate to ventricular fibrillation, in otherwise fit and healthy young people. Prevalence is at least 1 in 5000 and may be up to 1 in 1000. Clinical diagnosis is made from a combination of suspicious history, family history and the 12 lead ECG, which typically reveals a heart-rate corrected QT interval (QT//R–R interval = QTc) of greater than 0.46 s in women and 0.45 s in men. Exercise testing is often helpful in making the diagnosis. Clinical Presentation LQTS most commonly presents with syncope or sudden death during or following exercise or stress in a young person. Prolongation of QT can present on an incidental ECG, family screening or as sudden infant death. Misdiagnosis of LQTS as epilepsy, particularly “familial epilepsy”, is common. Seizures following exertion or arousal, even during sleep, must raise the suspicion of LQTS.
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View more >Definition and Prevalence Long QT syndrome (LQTS) is a familial condition causing syncope and sudden death through rapid ventricular tachycardia (torsade de pointes), which can deteriorate to ventricular fibrillation, in otherwise fit and healthy young people. Prevalence is at least 1 in 5000 and may be up to 1 in 1000. Clinical diagnosis is made from a combination of suspicious history, family history and the 12 lead ECG, which typically reveals a heart-rate corrected QT interval (QT//R–R interval = QTc) of greater than 0.46 s in women and 0.45 s in men. Exercise testing is often helpful in making the diagnosis. Clinical Presentation LQTS most commonly presents with syncope or sudden death during or following exercise or stress in a young person. Prolongation of QT can present on an incidental ECG, family screening or as sudden infant death. Misdiagnosis of LQTS as epilepsy, particularly “familial epilepsy”, is common. Seizures following exertion or arousal, even during sleep, must raise the suspicion of LQTS.
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Journal Title
Heart, Lung and Circulation
Volume
16
Subject
Cardiorespiratory Medicine and Haematology
Public Health and Health Services