Show simple item record

dc.contributor.authorA. Hume, Daviden_US
dc.contributor.authorWells, Christineen_US
dc.contributor.authorRavasi, Timothyen_US
dc.contributor.editorGregory Bock, Jamie Goodeen_US
dc.date.accessioned2017-05-03T15:01:01Z
dc.date.available2017-05-03T15:01:01Z
dc.date.issued2007en_US
dc.date.modified2008-07-08T05:14:07Z
dc.identifier.isbn9780470027554en_US
dc.identifier.urihttp://hdl.handle.net/10072/19636
dc.description.abstractThe functions of macrophages in the innate immune system require the constitutive expression of a wide range of myeloid-specific genes, including various pattern recognition receptors, as well as the inducible expression of a suite of genes required to initiate inflammation and eliminate pathogens. Our overall aim is to understand the transcriptional networks that underlie both macrophage-specific transcription and the response to pathogen components such as lipopolysaccharide (LPS). The approaches used include detailed functional analysis of specific promoters, such as that of the CSF1 receptor, global cDNA microarray expression profiling, high throughput real-time PCR analysis of all the transcription factors encoded by the mammalian genome, full length cDNA library construction and sequencing, CAGE analysis to identify specific promoters used in macrophages and motif analysis to detect candidate cis-acting elements in co-regulated genes in macrophages. This review discusses some of the progress in moving towards a transcriptional network model for mouse macrophage activation by LPS, as well as insight into the role of alternative promoter usage and polyadenylation in generating functional protein variants that impact on signalling in macrophages.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWileyen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofbooktitleDecoding the Genomic Control of Immune Reactionsen_US
dc.relation.ispartofchapter1en_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom2en_US
dc.relation.ispartofpageto24en_US
dc.relation.ispartofvolume281en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchHISTORY AND ARCHAEOLOGYen_US
dc.subject.fieldofresearchcode210000en_US
dc.titleTranscriptional regulatory networks in macrophagesen_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Book chapters
    Contains book chapters authored by Griffith authors.

Show simple item record