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  • Polydiscamides B–D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists

    Author(s)
    Feng, Yunjiang
    Carroll, Anthony R
    Pass, David M
    Archbold, Julia K
    Avery, Vicky M
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Carroll, Anthony R.
    Archbold, Julia
    Avery, Vicky M.
    Feng, Yun J.
    Pass, David
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
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    Journal Title
    Journal of Natural Products
    Volume
    71
    Issue
    1
    Publisher URI
    http://pubs.acs.org/loi/jnprdf
    DOI
    https://doi.org/10.1021/np070094r
    Copyright Statement
    © 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/20262
    Collection
    • Journal articles

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