Polydiscamides B–D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists
Author(s)
Feng, Yunjiang
Carroll, Anthony R
Pass, David M
Archbold, Julia K
Avery, Vicky M
Quinn, Ronald J
Year published
2008
Metadata
Show full item recordAbstract
Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
View less >
View less >
Journal Title
Journal of Natural Products
Volume
71
Issue
1
Publisher URI
Copyright Statement
© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine