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dc.contributor.authorYu, Xingen_US
dc.contributor.authorGuillion, Annabelen_US
dc.contributor.authorSzyczew, Alexanderen_US
dc.contributor.authorKiefel, Miltonen_US
dc.contributor.authorS. Coulson, Barbaraen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.authorBlanchard, Helenen_US
dc.date.accessioned2017-05-03T14:15:03Z
dc.date.available2017-05-03T14:15:03Z
dc.date.issued2008en_US
dc.date.modified2011-06-09T22:41:06Z
dc.identifier.issn17443091en_US
dc.identifier.urihttp://hdl.handle.net/10072/20267
dc.description.abstractInfectivity of rotavirus is dramatically enhanced by proteolytic cleavage of its outer layer VP4 spike protein into two function domains, VP8* and VP5*. The carbohydrate-recognising domain VP8* is proposed to bind sialic acid-containing host cell-surface glycans, followed by a series of subsequent virus-cell interactions. Live attenuated human and bovine rotavirus vaccine candidates to prevent gastroenteritis have been derived from bovine rotavirus strain NCDV. The NCDV VP8*64-224 was over-expressed, purified to homogeneity and crystallized in the presence of a N-acetylneuraminic acid derivative. X-ray diffraction data were collected to a resolution of 2.0 Šand the crystallographic structure of NCDV VP8*64-224 determined by molecular replacement.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Munksgaarden_US
dc.publisher.placeDenmarken_US
dc.publisher.urihttp://journals.iucr.org/f/issues/2008/06/00/issconts.htmlen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom509en_US
dc.relation.ispartofpageto511en_US
dc.relation.ispartofjournalActa Crystallographica Section F - Structural Biology and Crystallization Communicationsen_US
dc.relation.ispartofvolumeF64en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode329999en_US
dc.titleCrystallisation and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDVen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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