Show simple item record

dc.contributor.authorMueller, B
dc.contributor.authorAnissimov, YG
dc.contributor.authorRoberts, MS
dc.date.accessioned2017-05-03T15:14:02Z
dc.date.available2017-05-03T15:14:02Z
dc.date.issued2003
dc.date.modified2010-08-26T07:38:25Z
dc.identifier.issn0724-8741
dc.identifier.doi10.1023/B:PHAM.0000003382.20030.54
dc.identifier.urihttp://hdl.handle.net/10072/20302
dc.description.abstractPurpose. The validity of using drug amount-depth profiles in stratum corneum to predict uptake of clobetasol propionate into stratum corneum and its transport into deeper skin layers was investigated. Methods. In vitro diffusion experiments through human epidermis were carried out using Franz-type glass diffusion cells. A saturated solution of clobetasol propionate in 20% (V/V) aqueous propylene glycol was topically applied for 48 h. Steady state flux was calculated from the cumulative amount of drug permeated vs. time profile. Epidermal partitioning was conducted by applying a saturated drug solution to both sides of the epidermis and allowing time to equilibrate. The tape stripping technique was used to define drug concentration-depth profiles in stratum corneum for both the diffusion and equilibrium experiments. Results. The concentration-depth profile of clobetasol propionate in stratum corneum for the diffusion experiment is biphasic. A logarithmic decline of the drug concentration over the first four to five tape strips flattens to a relatively constant low concentration level in deeper layers. The drug concentration-depth profile for the equilibrium studies displays a similar shape. Conclusions. The shape of the concentration-depth profile of clobetasol propionate is mainly because of the variable partitioning coefficient in different stratum corneum layers.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeNew York
dc.relation.ispartofpagefrom1835
dc.relation.ispartofpageto1837
dc.relation.ispartofjournalPharmaceutical Research
dc.relation.ispartofvolume20
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3214
dc.titleUnexpected Clobetasol Propionate Profile in Human Stratum Corneum after Topical Application In Vitro.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorAnissimov, Yuri G.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record