Catheter Effects in Organ Perfusion Experiments.
Author(s)
Anissimov, YG
Bracken, AJ
Roberts, MS
Griffith University Author(s)
Year published
2002
Metadata
Show full item recordAbstract
In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration-time profile of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data.In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration-time profile of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data.
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Journal Title
Journal of Theoretical Biology
Volume
214
Publisher URI
Subject
Mathematical sciences
Biological sciences
Information and computing sciences