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dc.contributor.authorK. Coombes, Brian
dc.contributor.authorF. Brown, Nat
dc.contributor.authorKujat-Choy, Sonya
dc.contributor.authorA. Vallance, Bruce
dc.contributor.authorBrett Finlay, B.
dc.date.accessioned2017-05-03T12:25:13Z
dc.date.available2017-05-03T12:25:13Z
dc.date.issued2003
dc.date.modified2008-11-19T02:55:27Z
dc.identifier.issn12864579
dc.identifier.doi10.1016/S1286-4579(03)00094-7
dc.identifier.urihttp://hdl.handle.net/10072/20467
dc.description.abstractThe Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine model of systemic infection were used to address the role of an uncharacterized SPI2 open reading frame, designated as sseA, in Salmonella virulence. A Salmonella strain with an unmarked internal deletion of sseA displayed a phenotype that was similar to an SPI2-encoded type III secretion system apparatus mutant. Moreover, SseA was required for survival and replication within epithelial cells and macrophages. Murine infection studies confirmed that the ?sseA strain was severely attenuated for virulence. Using immunofluorescence microscopy, the virulence defect in the ?sseA strain was attributed to an inability to translocate SPI2 effector proteins into host cells. These data demonstrate that SseA is essential for SPI2-mediated translocation of effector proteins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/601557/description#description
dc.relation.ispartofpagefrom561
dc.relation.ispartofpageto570
dc.relation.ispartofissue7
dc.relation.ispartofjournalMicrobes and Infection
dc.relation.ispartofvolume5
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1107
dc.subject.fieldofresearchcode1108
dc.titleSseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorBrown, Nathaniel F.


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