Show simple item record

dc.contributor.authorC. Boyle, Erinen_US
dc.contributor.authorF. Brown, Naten_US
dc.contributor.authorH. Brumell, Johnen_US
dc.contributor.authorBrett Finlay, B.en_US
dc.date.accessioned2017-05-03T12:25:14Z
dc.date.available2017-05-03T12:25:14Z
dc.date.issued2007en_US
dc.date.modified2008-11-19T02:56:20Z
dc.identifier.issn14652080en_US
dc.identifier.doi10.1099/mic.0.2007/008581-0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/20475
dc.description.abstractThe ability of Salmonella enterica serovar Typhimurium (S. Typhimurium) to penetrate the intestinal epithelium is key to its pathogenesis. Bacterial invasion can be seen as a two-step process initially requiring adherence to the host cell surface followed by internalization into the host cell. Evidence suggests that adherence of S. Typhimurium to host cells is receptor-mediated; however, the host cell receptor(s) has/have not been identified. Internalization of S. Typhimurium absolutely requires the actin cytoskeleton yet only a few of the cytoskeletal components involved in this process have been identified. In order to identify host proteins that may play a role in S. Typhimurium invasion, the recruitment of actin-associated proteins was investigated. The contribution of recruited Src homology 2 adaptor proteins to invasion was further investigated and it was found that, while not involved in bacterial internalization itself, the adaptors Nck and ShcA influenced adherence of S. Typhimurium to non-phagocytic cells.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSociety for General Microbiologyen_US
dc.publisher.placeReading, England, UKen_US
dc.publisher.urihttp://mic.sgmjournals.org/en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom3517en_US
dc.relation.ispartofpageto3526en_US
dc.relation.ispartofissue10en_US
dc.relation.ispartofjournalMicrobiologyen_US
dc.relation.ispartofvolume153en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode270301en_US
dc.titleSrc homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2007
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record