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  • Development of seizure susceptibility is coincident with a tight time window that is required for accumulation of neural progenitors in the dorsal hippocampus .

    Author(s)
    Petcu, EB
    Sascau, M
    Sfredel, V
    Walker, LC
    Grisk, O
    Kessler, C
    Popa-Wagner, A
    Griffith University Author(s)
    Petcu, Eugen B.
    Popa-Wagner, Aurel
    Year published
    2007
    Metadata
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    Abstract
    Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Accumulating evidence suggests that neurogen-esis could be a major event that contributes to seizure susceptibility rather than a side effect of seizure activity. Recently we showed that optimal achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 ± 1 days. We hypothesized that neurogenesis-related cellular (survival) differentia-tion events with this periodicity may underlie the tightly circumscribed window for ...
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    Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Accumulating evidence suggests that neurogen-esis could be a major event that contributes to seizure susceptibility rather than a side effect of seizure activity. Recently we showed that optimal achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 ± 1 days. We hypothesized that neurogenesis-related cellular (survival) differentia-tion events with this periodicity may underlie the tightly circumscribed window for the optimal induction of convulsive seizure. By real-time PCR, quantitative immunohistochemistry and confocal 3D-image reconstruction analysis using tissue from this new model, we now re-port that convulsive seizure leads first to a non-specific, transient in-crease in the number of proliferative cells that express the proliferating cell nuclear antigen-, nestin-, ßIII-tubulin and doublecortin. However, repeated convulsive seizures with a periodicity of 25 days led to a massive and selective increase in the number of new-born cells expressing the neuronal lineage marker, doublecortin, at the boundary between the granule cell layer and the polymorphic layer in the dorsal hippocampus.
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    Conference Title
    ACTA NEUROPATHOLOGICA
    Volume
    114
    Issue
    3
    DOI
    https://doi.org/10.1007/s00401-007-0265-y
    Subject
    Clinical sciences
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/20633
    Collection
    • Conference outputs

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