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  • Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae

    Author(s)
    M. Grant, Chris
    Luikenhuis, Sandra
    Beckhouse, Anthony
    Soderbergh, Malin
    W. Dawes, Ian
    Griffith University Author(s)
    Beckhouse, Anthony G.
    Year published
    2000
    Metadata
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    Abstract
    Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We report here that the expression of both genes is induced in response to various stress conditions including oxidative, osmotic, and heat stress and in response to stationary phase growth and growth on non-fermentable carbon sources. Furthermore, both genes are activated by the high-osmolarity glycerol pathway and negatively regulated by the Ras-protein kinase A pathway via stress-responsive STRE elements. GRX1 contains a single ...
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    Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We report here that the expression of both genes is induced in response to various stress conditions including oxidative, osmotic, and heat stress and in response to stationary phase growth and growth on non-fermentable carbon sources. Furthermore, both genes are activated by the high-osmolarity glycerol pathway and negatively regulated by the Ras-protein kinase A pathway via stress-responsive STRE elements. GRX1 contains a single STRE element and is induced to significantly higher levels compared to GRX2 following heat and osmotic shock. GRX2 contains two STRE elements, and is rapidly induced in response to reactive oxygen species and upon entry into stationary phase growth. Thus, these data support the idea that the two glutaredoxin isoforms in yeast play distinct roles during normal cellular growth and in response to stress conditions
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    Journal Title
    Biochimica et Biophysica Acta - Gene Structure and Expression
    Volume
    1490
    Issue
    1-2
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/713381/description?navopenmenu=-2
    DOI
    https://doi.org/10.1016/S0167-4781(99)00234-1
    Subject
    Genetics
    Publication URI
    http://hdl.handle.net/10072/20985
    Collection
    • Journal articles

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