dc.contributor.author | Whitbread, AK | |
dc.contributor.author | Mellick, GD | |
dc.contributor.author | Silburn, PA | |
dc.contributor.author | Le Couteur, DG | |
dc.contributor.author | Board, PG | |
dc.date.accessioned | 2017-05-03T14:10:47Z | |
dc.date.available | 2017-05-03T14:10:47Z | |
dc.date.issued | 2004 | |
dc.date.modified | 2009-09-23T02:38:12Z | |
dc.identifier.issn | 0028-3878 | |
dc.identifier.doi | 10.1212/01.WNL.0000125282.09308.B1 | |
dc.identifier.uri | http://hdl.handle.net/10072/21045 | |
dc.description.abstract | Within 1 the glutathione transferase (GST) superfamily, the Omega class contains two expressed genes (hGSTO1 and hGSTO2) and one pseudogene (hGSTO3p). 1 The hGSTO1 and hGSTO2 genes lie 7.5 kb apart on chromosome 10q24.3, 1 between the markers D10S603 and D10S597. This region overlaps the D10S1239-D10S1237 interval implicated in age at onset (AAO) of Alzheimer disease (AD) and Parkinson disease (PD). 2 We previously identified three polymorphisms in hGSTO genes: hGSTO1*A140D, hGSTO1*E155del, and hGSTO2*N142D. 1 Omega class GSTs regenerate ascorbate, 3 an important antioxidant in the brain. Additionally, GSTO1-1 may activate interleukin-1[beta] 4 and contribute to inflammation, which is implicated in AD and PD pathogenesis. We investigated the relationship between known GST Omega polymorphisms and PD. After this study was initiated, others confirmed a link between GSTO and PD. 5 | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.neurology.org/ | |
dc.relation.ispartofpagefrom | 1910 | |
dc.relation.ispartofpageto | 1911 | |
dc.relation.ispartofissue | 10 | |
dc.relation.ispartofjournal | Neurology | |
dc.relation.ispartofvolume | 62 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Glutathione transferase Omega class polymorphisms in Parkinson’s disease. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2004 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information. | |
gro.date.issued | 2004 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Mellick, George | |