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dc.contributor.authorWhitbread, AK
dc.contributor.authorMellick, GD
dc.contributor.authorSilburn, PA
dc.contributor.authorLe Couteur, DG
dc.contributor.authorBoard, PG
dc.date.accessioned2017-05-03T14:10:47Z
dc.date.available2017-05-03T14:10:47Z
dc.date.issued2004
dc.date.modified2009-09-23T02:38:12Z
dc.identifier.issn0028-3878
dc.identifier.doi10.1212/01.WNL.0000125282.09308.B1
dc.identifier.urihttp://hdl.handle.net/10072/21045
dc.description.abstractWithin 1 the glutathione transferase (GST) superfamily, the Omega class contains two expressed genes (hGSTO1 and hGSTO2) and one pseudogene (hGSTO3p). 1 The hGSTO1 and hGSTO2 genes lie 7.5 kb apart on chromosome 10q24.3, 1 between the markers D10S603 and D10S597. This region overlaps the D10S1239-D10S1237 interval implicated in age at onset (AAO) of Alzheimer disease (AD) and Parkinson disease (PD). 2 We previously identified three polymorphisms in hGSTO genes: hGSTO1*A140D, hGSTO1*E155del, and hGSTO2*N142D. 1 Omega class GSTs regenerate ascorbate, 3 an important antioxidant in the brain. Additionally, GSTO1-1 may activate interleukin-1[beta] 4 and contribute to inflammation, which is implicated in AD and PD pathogenesis. We investigated the relationship between known GST Omega polymorphisms and PD. After this study was initiated, others confirmed a link between GSTO and PD. 5
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.publisher.urihttp://www.neurology.org/
dc.relation.ispartofpagefrom1910
dc.relation.ispartofpageto1911
dc.relation.ispartofissue10
dc.relation.ispartofjournalNeurology
dc.relation.ispartofvolume62
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleGlutathione transferase Omega class polymorphisms in Parkinson’s disease.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2004 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


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