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  • Colloidal metallic gold is not bio-inert

    Author(s)
    Brown, CL
    Whitehouse, MW
    Tiekink, ERT
    Bushell, GR
    Griffith University Author(s)
    Brown, Chris L.
    Bushell, Gillian R.
    Tiekink, Edward RT.
    Whitehouse, Michael
    Year published
    2008
    Metadata
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    Abstract
    Metallic gold (Au੠is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Auࠢeing formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats ...
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    Metallic gold (Au੠is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Auࠢeing formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.
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    Journal Title
    Inflammopharmacology
    Volume
    16
    DOI
    https://doi.org/10.1007/s10787-007-0017-6
    Subject
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/21294
    Collection
    • Journal articles

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