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  • The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

    Author(s)
    Wells, Christine
    Salvage-Jones, Judith
    Li, Xin
    Hitchens, Kelly
    Butcher, Suzanne
    Z. Murray, Rachel
    Beckhouse, Anthony
    Lo, Yu-Lan Sandra
    Manzanero Alonso, Silvia
    Cobbold, Christian
    Schroder, Kate
    Ma, Bo
    Orr, Sally
    Stewart, Lauren
    Lebus, Daniel
    Sobieszczuk, Peter
    A. Hume, David
    Stow, Jennifer
    Blanchard, Helen
    Ashman, Robert
    Griffith University Author(s)
    Salvage-Jones, Judith A.
    Blanchard, Helen
    Lo, Yu-Lan Sandra S.
    Butcher, Suzanne
    Hitchens, Kelly J.
    Wells, Christine
    Cobbold, Christian J.
    Ashman, Robert B.
    Beckhouse, Anthony G.
    Manzanero Alonso, Silvia
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-{alpha} by macrophages was reduced, ...
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    The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-{alpha} by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.
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    Journal Title
    Journal of Immunology
    Volume
    180
    Issue
    11
    Publisher URI
    http://www.jimmunol.org/content/180/11/7404.short
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Immunology
    Publication URI
    http://hdl.handle.net/10072/21351
    Collection
    • Journal articles

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