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dc.contributor.authorWells, Christineen_US
dc.contributor.authorSalvage-Jones, Judithen_US
dc.contributor.authorLi, Xinen_US
dc.contributor.authorHitchens, Kellyen_US
dc.contributor.authorButcher, Suzanneen_US
dc.contributor.authorZ. Murray, Rachelen_US
dc.contributor.authorBeckhouse, Anthonyen_US
dc.contributor.authorLo, Yu-Lan Sandraen_US
dc.contributor.authorManzanero Alonso, Silviaen_US
dc.contributor.authorCobbold, Christianen_US
dc.contributor.authorSchroder, Kateen_US
dc.contributor.authorMa, Boen_US
dc.contributor.authorOrr, Sallyen_US
dc.contributor.authorStewart, Laurenen_US
dc.contributor.authorLebus, Danielen_US
dc.contributor.authorSobieszczuk, Peteren_US
dc.contributor.authorA. Hume, Daviden_US
dc.contributor.authorStow, Jenniferen_US
dc.contributor.authorBlanchard, Helenen_US
dc.contributor.authorAshman, Roberten_US
dc.contributor.editorJeremy M. Bossen_US
dc.description.abstractThe recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-{alpha} by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.en_US
dc.publisherAmerican Association of Immunologistsen_US
dc.publisher.placeBethesda MDen_US
dc.relation.ispartofjournalJournal of Immunologyen_US
dc.titleThe macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicansen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.hasfulltextNo Full Text
gro.griffith.authorLo, Yu-Lan Sandra S.
gro.griffith.authorManzanero Alonso, Silvia
gro.griffith.authorCobbold, Christian J.
gro.griffith.authorBlanchard, Helen
gro.griffith.authorAshman, Robert B.
gro.griffith.authorWells, Christine
gro.griffith.authorSalvage-Jones, Judith A.
gro.griffith.authorHitchens, Kelly J.
gro.griffith.authorButcher, Suzanne
gro.griffith.authorBeckhouse, Anthony G.

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