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dc.contributor.authorShen, Xiaoyun
dc.contributor.authorLam, P.
dc.contributor.authorShaw, G.
dc.contributor.authorWickramasinghe, W.
dc.date.accessioned2017-05-03T11:10:38Z
dc.date.available2017-05-03T11:10:38Z
dc.date.issued2002
dc.date.modified2009-02-27T06:44:38Z
dc.identifier.issn00410101
dc.identifier.doi10.1016/S0041-0101(02)00151-4
dc.identifier.urihttp://hdl.handle.net/10072/21491
dc.description.abstractCylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock. In this study, Balb/c mice were injected via the intraperitoneal (IP) route with a single dose of 0.2 mg/kg CYN. Animals were sacrificed at 6, 12, 24, 48 and 72 h. DNA was isolated from the mouse livers, and examined for strand breakage by alkaline gel electrophoresis (pH 12). Significant DNA strand breakage was observed in the mouse liver exposed to CYN, suggesting that induction of DNA strand breakage is probably one of the key mechanisms for CYN genotoxicity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeAmsterdam
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00410101
dc.relation.ispartofpagefrom1499
dc.relation.ispartofpageto1501
dc.relation.ispartofissue10
dc.relation.ispartofjournalToxicon
dc.relation.ispartofvolume40
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode1115
dc.titleGenotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2002
gro.hasfulltextNo Full Text
gro.griffith.authorShaw, Glendon R.


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