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  • A model to study intestinal and hepatic metabolism of propranolol in the dog

    Author(s)
    Mills, P.
    Siebert, G.
    Roberts, M.
    Griffith University Author(s)
    Siebert, Gerhard
    Year published
    2004
    Metadata
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    Abstract
    A model to investigate hepatic drug uptake and metabolism in the dog was developed for this study. Catheters were placed in the portal and hepatic veins during exploratory laparotomy to collect pre- and posthepatic blood samples at defined intervals. Drug concentrations in the portal vein were taken to reflect intestinal uptake and metabolism of an p.o. administered drug (propranolol), while differences in drug and metabolite concentrations between portal and hepatic veins reflected hepatic uptake and metabolism. A significant difference in propranolol concentration between hepatic and portal veins confirmed a high hepatic ...
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    A model to investigate hepatic drug uptake and metabolism in the dog was developed for this study. Catheters were placed in the portal and hepatic veins during exploratory laparotomy to collect pre- and posthepatic blood samples at defined intervals. Drug concentrations in the portal vein were taken to reflect intestinal uptake and metabolism of an p.o. administered drug (propranolol), while differences in drug and metabolite concentrations between portal and hepatic veins reflected hepatic uptake and metabolism. A significant difference in propranolol concentration between hepatic and portal veins confirmed a high hepatic extraction of this therapeutic agent in the dog. This technically uncomplicated model may be used experimentally or clinically to determine hepatic function and metabolism of drugs that may be administered during anaesthesia and surgery.
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    Journal Title
    Journal of Veterinary Pharmacology and Therapeutics
    Volume
    27
    Issue
    1
    DOI
    https://doi.org/10.1111/j.1365-2885.2004.00547.x
    Subject
    Veterinary Sciences
    Publication URI
    http://hdl.handle.net/10072/21556
    Collection
    • Journal articles

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