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dc.contributor.authorAlayan, J
dc.contributor.authorIvanovski, S
dc.contributor.authorGemmell, E
dc.contributor.authorFord, P
dc.contributor.authorHamlet, S
dc.contributor.authorFarah, CS
dc.contributor.editorJoergen Slots
dc.date.accessioned2017-05-03T15:05:28Z
dc.date.available2017-05-03T15:05:28Z
dc.date.issued2006
dc.date.modified2009-03-02T06:52:03Z
dc.identifier.issn0902-0055
dc.identifier.doi10.1111/j.1399-302X.2006.00304.x
dc.identifier.urihttp://hdl.handle.net/10072/21577
dc.description.abstractPeriodontitis is a chronic inflammatory disease that results in extensive soft and hard tissue destruction of the periodontium. Porphyromonas gingivalis possesses an array of virulence factors and has been shown to induce expression of inducible nitric oxide synthase (iNOS) in inflammatory cells. The aim of this study was to investigate the effect of eliminating iNOS in a murine model of P. gingivalis infection. This was achieved by utilizing a P. gingivalis-induced skin abscess model, and an alveolar bone loss model employing an oral infection of P. gingivalis in iNOS knockout mice. The results indicated that iNOS knockout mice exhibit more extensive soft tissue damage and alveolar bone loss in response to P. gingivalis infection compared to wild-type mice. The local immune response to P. gingivalis in iNOS knockout mice was characterized by increased numbers of polymorphonuclear monocytes, while the systemic immune response was characterized by high levels of interleukin-12. The iNOS is required for an appropriate response to P. gingivalis infection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Munkgaard
dc.publisher.placeDenmark
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom360
dc.relation.ispartofpageto365
dc.relation.ispartofjournalOral Microbiology and Immunology
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3207
dc.titleDeficiency of iNOS contributes to Porphyromonas gingivalis - induced tissue damage
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorHamlet, Stephen


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