Show simple item record

dc.contributor.authorBugarcic, Andreaen_US
dc.contributor.authorHitchens, Kellyen_US
dc.contributor.authorBeckhouse, Anthonyen_US
dc.contributor.authorWells, Christineen_US
dc.contributor.authorAshman, Roberten_US
dc.contributor.authorBlanchard, Helenen_US
dc.contributor.editorRonald Schnaaren_US
dc.date.accessioned2017-04-24T11:30:08Z
dc.date.available2017-04-24T11:30:08Z
dc.date.issued2008en_US
dc.date.modified2009-03-03T22:29:23Z
dc.identifier.issn09596658en_US
dc.identifier.doi10.1093/glycob/cwn046en_AU
dc.identifier.urihttp://hdl.handle.net/10072/21597
dc.description.abstractCandida albicans is a causative agent in mycoses of the skin, oral cavity and gastrointestinal tract. Identification of receptors, and their respective ligands, that are engaged by immune cells when in contact with C. albicans is crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle is a recently identified macrophage-expressed receptor that is important for host responses to C. albicans. The carbohydrate-recognition domain of human and mouse Mincle were expressed, purified under denaturing conditions and successfully refolded. In addition to oligomers, there are isolatable monomeric and dimeric forms of the protein that occur under two different buffer solutions. The human and mouse homologues bound yeast extract, and the isolated dimeric and monomeric species also demonstrated recognition of whole C. albicans yeast cells. The data is indicative of several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://glycob.oxfordjournals.org/en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom679en_US
dc.relation.ispartofpageto685en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalGlycobiologyen_US
dc.relation.ispartofvolume18en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250503en_US
dc.titleHuman and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicansen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.rights.copyrightCopyright 2008 Oxford University Press. Please refer to the link for the definitive publisher-authenticated version.en_AU
gro.date.issued2008
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record